Any anime that has a classroom setting probably has this. What is it? You probably wouldn't notice it unless someone brought it up. Let's take a look at some pictures, then find out what they all have in common.

Seitokai Yakuindomo

A Certain Magical Index

Heroman

Code Geass

Kimi ni Todoke

Yes, the main characters are all sitting in the exact same spot.  Some other anime characters that share this spot would include Light in Death Note, Rei in Evangelion, Kyon and Haruhi in The Melancholy of Haruhi Suzumya... well you get the point. 

The significance of this spot?  Well in Death Note, Light is able to notice the book outside the window from that position.  But other than that, I don't know if there is a specific reason.  I think they're there so they can have plot defining monologues, or just to look out the window dreamily while the narrator reiterates said plot.  Or maybe it's just so they can eat and sleep unnoticed by the teacher.